Addisons Disease in Dogs:

Addisons Disease in dogs is brought on by an imbalance in hormonal output. How dogs have been able to overcome this imbalance naturally for thousands of years without toxic prescription drugs or harmful steroids is a question we had to ask.

Primalix Adadren for Adrenal Gland Support in Dogs 4 oz bottle

Addison's Disease is a devastating condition that is believed to be an autoimmune disease. It is seen more commonly in female dogs than male dogs and doesn't normally come out until the dog is at least five and a half years old. This genetic disease is progressive and has no cure, although it can be managed.

If Left Untreated

Untreated, Addison's disease leads to an Addisonian crisis and possible death. Addisons disease in dogs occurs when the body's immune system begins attacking the adrenal glands. This happens when the immune system fails to recognize the body’s own cells, treating them as foreign invaders.

Why are Adrenal Glands Important?

The adrenal glands are essential for a variety of body regulating functions including the production of important hormones like the stress hormone cortisol, and aldosterone. The adrenal glands also replenish electrolytes. Electrolytes like potassium and sodium regulate water intake and heart function. When production is damaged due to adrenal glands that are under attack, dogs can become dehydrated, develop an irregular heartbeat, or even go into renal failure.

The opposite of Addison's disease is Cushing's disease in which adrenal hormones including cortisol are overproduced instead of under produced. There is also a recommended safe and effective herbal dietary supplement for Cushing's in dogs.

Older dog awaiting his dose of Primalix Adadren for Addisons Disease in dogs.

Symptoms of Addison’s Disease

The progression of Addisons disease in dogs can be subtle and effect many bodily processes. While owners may suspect that something isn't right, they may not recognize this dangerous disease until the later stages. As the progression of Addison's disease continues, you are likely to see the following symptoms.

     Lack of interest in food, vomiting after drinking water, and diarrhea

     General weakness and lethargy progressing to extreme weakness and dehydration

     Extremely high potassium levels and very low sodium levels

     Erratic heartbeat and loss of function in kidneys

Following these symptoms the dog will go into an Addisonian crisis, which is a medical emergency from which dogs may or may not recover. It is essential to try to recognize Addison's early and get timely medical attention.

Living with Addisons Disease in Dogs

While Addisons disease in dogs can't be cured, it can be medically managed so that your dog can have a good quality of life. Generally, your veterinarian will begin treatment with a corticosteroid. Doses are high at first and then reduced as electrolyte levels normalize. The steroid dose that will need to be maintained in order to keep your dog symptom-free varies by dog, but all dogs will need to stay on a steroid in order to prevent the disease from progressing. Steroids affect many aspects of your dog's life including food drive and aggression and may lead to related long-term health problems like diabetes.

Stress and Addisons Disease in Dogs

Because Addison's disease attacks adrenal glands which are responsible for producing the stress hormone cortisol, dogs that suffer from Addison's disease have a struggle with stress. Cortisol produces the fight or flight response which is essential to survival but damaging in domestic situations. Dogs may be inappropriately terrified of new people, traveling, thunderstorms, fireworks, etc., and sometimes our dogs just need to chill out. You can use this safe and natural herbal dog anxiety rescue when your Addison's dog is dealing with extra stress.

Adadren graphic: Clinical studies show...

A Natural Steroid?

Thankfully, there are herbs that Naturpoathic doctors use instead of chemical steroidal drugs, without negative side effects. These herbs have been used safely and effectively throughout history to support a healthy adrenal cortex which then normalizes cortisol production and allows the body to naturally reduce symptoms. These special herbs make up the ingredients in our Primalix® AdadrenTM for Dogs.

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Graphic: Our alcohol-free glycerites provide up to 5 times more absorption than pills...

What is it?

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     Primalix® AdadrenTM is an organic herbal remedy that nourishes physiological imbalances in dogs of all breeds

     Herbs used for thousands of years and clinically proven in today’s laboratories to support healthy adrenal gland function

     Easy to use Functional Food Drops: simply add to your dog's food or give by mouth as directed on the label

     Clinical studies show that naturally healthy adrenal glands stabilize potassium levels and normalize the production of cortisol

Key benefits

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Graphic: Our bottles are twice as big as others'.

     Non-steroidal: free of short and long-term steroidal side effects

     Used for immediate support - ideal for long term dietary maintenance  

     Easy to add to your dog's feeding routine

     Keeps your dog safe from drugs while nourishing and fortifying the adrenal glands


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Graphic: All ingredients are USDA Certified Organic...

Rehmannia root (Rehmania glutinosa) is considered a longevity tonic in traditional Chinese medicine where it has been used for thousands of years as one of the essential herbs for a range of ailments from diabetes to urinary incontinence. Among the chief constituents of Rehmannia root are iridoid glycosides, simple glucose molecules known to stimulate the adrenal glands to produce cortisol.

An animal clinical test in Beijing showed Rehmannia root extract to be effective when used concurrently with dexamethasone. Plasma corticosterone concentrations were dropping dangerously before treatment but began to reverse and normalize within four to six weeks of the combined herbal and conventional therapy. The study indicates that the use of Rehmannia root in addition to conventional treatment is even more effective than conventional treatment alone.1

Raw Licorice Sticks

Licorice (Glycyrrhiza glabra) has been used in both Eastern and Western medicine and culinary arts for thousands of years. It has a wide range of medicinal uses, including positive benefits for Addisons disease in dogs.

A clinical study published in the New Zealand Veterinary Journal, 53(3) 2005 examines the case of a four year old male dog who had been diagnosed with Addison's. The dog had persistent high potassium levels despite receiving a dose of fludrocortisone. Researchers were able to bring potassium levels back to normal by adding whole licorice to the dog's diet, thereby finding licorice to be a “useful adjunct in the management of canine hypoadreno-corticism.”2

Graphic: Functional Food Drops for your convenience.

Astragalus is a powerful multi-functional herb that is safe enough to use as a general health tonic but effective enough to have meaningful effects on a wide range of maladies. It has been used for centuries in traditional Chinese medicine for its immune-boosting and anti-aging effects. In Addisons disease in dogs, Astragalus may aid a struggling immune system and encourage the body to fight off viruses that burden the adrenal glands.

Gentian root is a slow growing herb from the Alps and Himalayas. It has been used in European herbal medicine for over 2000 years and was said to have been discovered by Gentius, King of ancient Illyria, from whom it gets its name. Naturopathic physicians claim it is wonderfully effective against all sorts of digestive upsets, including appetite loss, gas, diarrhea, heartburn, etc. It also has germicidal properties, elevates the appetite and assists the immune system.

Ginger is well-known for its culinary contribution and stomach-soothing qualities. It has been used for these purposes for thousands of years with significant applications for Addisons disease in dogs. It has been used to stimulate bowel movements, ease nausea, and soothe intestinal issues.

Dosing instructions

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Dropper instructions

Add to food:

Small Dogs (under 21 lbs) 1 dropper twice daily
Medium Dogs (21 to 60 lbs) 2 droppers twice daily
Large Dogs (61 to 100 lbs) 3 droppers twice daily
Giant Dogs (101 lbs and up) 4 droppers twice daily

NOTE: One "dropper" equals one squeeze of the black bulb (1.0mL), which fills the pipette about half full. Refrigerate after opening. Add to food or give by mouth.

Product guarantee

Our Risk-Free Guarantee

“Every bottle of Primalix ® Adadren TM for Adrenal Gland Support in Dogs is guaranteed to meet your complete satisfaction or your money back! Simply return the unused portion to Natural Wonder Products within 30 days for a full refund of your purchase price (less S&H). No hassle, no questions asked. If you’re not happy, we’re not happy!”

Primalix Adadren for Adrenal Gland Support in Dogs 4 oz bottle
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1. (Wang, Y.S. (1983) Pharmacology and Applications of Chinese Materia Medico, pp. 400-406. Beijing: People's Health Publisher.)
2. New Zealand Veterinary Journal, 53(3) 2005