Addison's Disease in Dogs:

Herbal Adjunct to Conventional Treatment
or Primary Natural Remedy?
Your Choice.

Addison's Disease in Dogs

Conventional treatment for Addison's disease in dogs (hypoadreno-corticism) may have found some new best friends: herbs.

Clinical studies show dogs'

  • electrolytes returning to normal
  • adrenal hormones flourishing, and
  • cortisol uptake achieving normal balance

when specific herbs are used as an adjunct to corticosteroids, "...significantly more than when these herbs are not used."1

Even more impressive is the healing at the glandular level. We address this by combining one of the most trusted herbs in Traditional Chinese Medicine (TCM) with four of the most researched herbs in our own Western naturopathic medicine.

This meeting of Eastern and Western herbal medicine is equal to more than the sum of the parts. These five legendary herbs act to correct hormonal imbalances with a synergy that conventional medicine can't touch. Our proprietary formula is holistic while acting on the adrenal glands. Healing follows naturally as specific nutrients feed not only the system but the whole body. You simply add our extract in the form of Functional Food Drops TM to wet or dry dog food as directed on the label.

Primalix Adadren targets all symptoms of Addison's disease in all dog breeds. Given as an adjunct to steroids or as the sole acting agent, Primalix Adadren is a safe and effective herbal remedy for under-performing canine adrenal glands. More below.

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Understanding the condition

Addison's disease, which is more commonly seen in female dogs, doesn’t usually present until the dog is about 5.5 years old. The disease is genetic and progresses as the dog’s adrenal glands atrophy.

Dog owners don’t normally detect something is wrong with the pet until the dog begins to display severe lethargy. It’s at this time the dog could go through an Addisonian crisis, which is a dangerous condition that, left untreated, often leads to death.

What Causes Addison’s Disease?

The disease is thought to be an autoimmune disorder. An autoimmune disorder occurs when the body’s immune system does not recognize “self.” Recognizing “self” is the main trigger that stops an immune cell from attacking the body’s own cells. When this trigger is genetically altered, the immune system hunts down and kills its own organ cells. In the case of Addison’s disease, the dog’s immune system destroys the adrenal glands with military precision.

What is the Function of Adrenal Glands?

Adrenal glands are located next to the kidneys and produce hormones including cortisol and aldosterone. The shape and color of pink jelly beans, these glands are necessary for body regulation including the replenishment of electrolytes when levels are low.

Electrolytes are ions such as potassium and sodium that regulate water intake and heart function. When these electrolytes are unbalanced, it leads to dehydration, heart irregularity and even renal failure. Severely unbalanced electrolyte levels are seen when a dog develops Addison’s disease and goes through an Addisonian crisis.

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What are the Symptoms of Addison’s Disease?

Because a dog can’t articulate that there is something wrong, dog owners usually sense the disease beginning with extreme lethargy.

  • The dog won’t eat and is unable to drink water without vomiting.
  • Diarrhea and weakness are also seen
  • As the disease progresses, the dog becomes more weak and dehydrated
  • Potassium levels skyrocket and sodium levels are severely reduced
  • The heart beat becomes erratic and kidneys lose function

An Addisonian crisis is a medical emergency. What's important here is to get the dog to a medical facility immediately, where the illness can be properly treated.

Dog’s Living with Addison’s Disease

Fortunately, after the disease is diagnosed and treated, the dog can live a long, normal life with continuing medication. Mind you, we're talking lifelong treatment that involves steroid medication and continuous monitoring. Your veterinarian will typically begin treatment with a corticosteroid, changing the dose as electrolyte levels normalize.

Stress is the watchword for Addison's Disease in Dogs

Remember how the function of the adrenal glands is to produce life-essential hormones? Topping the hormone hierarchy is cortisol, which is produced during times of stress - better known as the fight or flight response.

Stress is the watchword for the responsible dog lover. We don't want to impede cortisol production or risk adverse interaction with existing meds, whether prescription, herbal, or both. But sometimes we just want doggie to chill. This safe and effective herbal dog anxiety medication may come in handy during times of extra tension such as

  • A new person or dog entering the home
  • Going on long road trips
  • Activities during the holidays when people come in and go out of the home
  • Fireworks and thunderstorms
Dogs with Addison's disease suffer from an under-production of adrenal hormones including cortisol. The opposite of this condition is an over-production of cortisol, which is called Cushing's disease. Fortunately, there is a safe and effective herbal treatment for Cushing's in dogs.

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What About Alternative Herbal Therapy?

Primalix® AdadrenTM is the ideal adjunct to conventional veterinary steroidal treatment. Or, as holistic veterinarians may prefer, the formula can be used as the primary agent to relieve symptoms of Addison's in dogs, without the adverse side effects of "roids."

Herbal ingredients include our proprietary blend of USDA Certified Organic
Rehmannia root
Gentian root
Ginger root

Historically, these herbs have been used to safely and effectively nourish the adrenal cortex, normalize cortisol production, and reduce the symptoms of Addison's disease in dogs. The AdadrenTM formula is available only from Natural Wonder Pets.


Rehmannia root (Rehmania glutinosa) is known as Di-huang in Traditional Chinese Medicine where it has served for thousands of years as one of 50 fundamental herbs. Considered a longevity tonic, it restores yin deficiency and nourishes a host of ailments from diabetes to urinary incontinence.

Among the chief constituents of Rehmannia root are iridoid glycosides, simple glucose molecules that stimulate the production of cortisol in the adrenal glands. The herb has performed well under many clinical studies including one animal test in Beijing.

This trial showed Rehmannia root extract to be an effective adjunct when used concurrently with dexamethasone. Plasma corticosterone concentrations that were dropping dangerously began to reverse and normalize within 4 to 6 weeks of combined herbal and conventional therapy.1

Licorice (Glycyrrhiza glabra) is a wild perennial that has been used in both Eastern and Western medicine for thousands of years. One recent clinical study published in the New Zealand Veterinary Journal, 53(3) 2005, examined the effects of the whole herb on a four year old neutered male patient.

Raw Licorice Sticks

The dog had been diagnosed with Addison's and had maintained persistently high potassium levels (hyperkalaemia) despite receiving a moderate dose of fludrocortisone. By adding licorice to the dog's diet, researchers were able to bring potassium levels back to normal. They stated, “Given these very preliminary findings, we believe it is possible that liquorice may, in future, prove to be a useful adjunct in the management of canine hypoadreno-corticism.”2

And so, if you opt for conventional veterinary treatment as your primary Addison's therapy, it seems your dog will benefit even more with the addition of Nature's original medicine - blessed herbs!

Lady with mortar and pestle
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Full Spectrum, Full Formula, Fully Un-Denatured

Our extraction solvent (menstruum) consists of our own proprietary blend of organic vegetable glycerin, apple cider vinegar, and crystal clear water which we ionize and purify through filters measuring one one-hundredth of a micron. We do not extract with alcohol, which is harmful to dogs and cats, nor with heat which "denatures" the very herbal constituents that do the healing.

Our herbs are organically cultivated (USDA Certified Organic or Wildharvested) to maintain purity. Then we place them into our Full Spectrum extraction process, one precious gallon at a time, at the peak of their potency cycle, for no less than a fortnight.

Ours is a time-honored tradition of tincturing that assures the constituent ratios in our extracts are identical to the synergistic nutrient ratios in the plants used.

We make and sell only our own products, so we know exactly what’s in them. We know of no other herbal extraction method that so painstakingly prepares Nature's bounty for our beloved animal companions.


Turn Ordinary Food Into Functional FoodSM

Our Primalix ® Adadren TM for Adrenal Gland Support in Dogs - Functional Food Drops TM - let you add specific, beneficial, physiologically active food components (herbal nutrients) to wet or dry food.

Functional food is any food having health-promoting or disease-preventing properties beyond the basic function of supplying nutrients.

Nearly 2500 years ago Hippocrates said, “Let food be thy medicine and medicine be thy food.”

Animals do this instinctively. In the wild they “functionalize” their food by sniffing out and eating specific herbs to prevent disease and maintain natural wellness.

Now you can add function to any dry, canned, raw or homemade pet food. Give your domestic dog or cat a targeted dose of wild, natural wellness with every meal.

Dropper instructions
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Dosing Instructions

Add to food:
Small Dogs (under 21 lbs) 1 dropper twice daily
Medium Dogs (21 to 60 lbs) 2 droppers twice daily
Large Dogs (61 to 100 lbs) 3 droppers twice daily
Giant Dogs (101 lbs and up) 4 droppers twice daily

NOTE: One "dropper" equals one squeeze of the black bulb (1.0mL), which fills the pipette about half full. Refrigerate after opening. Add to food or give by mouth.

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Addison's in CATS: Rarely does Addison's occur in cats and only occasionally in kittens. We do not make a Primalix Adadren for Cats, but the herbs would be essentially the same as those in our formula for Dogs if we did. You may give our Adadren for Dogs to kittens and adult cats in the following dosages:

Kittens: 1/4 dropper twice daily

Cats: 1/2 dropper twice daily

Product guarantee

Our Risk-Free Guarantee*

We're so sure you are going to be completely satisfied with Primalix® Adadren TM for Adrenal Gland Support in Dogs - Functional Food DropsTM - that you have our ironclad, bottom-of-the-bottle Written Guarantee:

“Every bottle of Primalix ® Adadren TM for Adrenal Gland Support in Dogs is guaranteed to meet your complete satisfaction or your money back! Simply return the unused portion to Natural Wonder Products within 30 days for a full refund of your purchase price (less S&H). No hassle, no questions asked. If you’re not happy, we’re not happy!”

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Primalix® Adadren TM for adrenal gland support in Dogs - Herbal Extract - Functional Food Drops TM - $39.95 (Regular price $49.95) - 4 oz Glycerite (Amber Glass Tincture - no alcohol) Contains 120 droppers full. USDA Certified Organic, human grade ingredients. Up to 5 times more absorption than pills, tablets or granules. $10 INSTANT REBATE

Primalix Adadren for Adrenal Gland Support in Dogs
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YOU GET TWICE AS MUCH: All Primalix® products are 4 fl oz, giving you 2 to 4 times more medicine than our competitors' 1 or 2 ounce bottles that cost about the same and may contain harmful alcohol.

Limited Time Offer:

Now, for a limited time, buy 3 bottles of Primalix® AdadrenTM for Adrenal Gland Support in Dogs - Functional Food DropsTM - Regular price $149.85. Now only $119.85. >>SAVE $30.00 TODAY<<

Primalix Adadren for adrenal gland support in dogs - 3 bottles
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Back to Top - Addisons Disease in Dogs

1. (Wang, Y.S. (1983) Pharmacology and Applications of Chinese Materia Medico, pp. 400-406. Beijing: People's Health Publisher.)
2. New Zealand Veterinary Journal, 53(3) 2005