Symptoms of Cushings in Dogs Quelled
With Ancient Herbs & Modern Science

Cushings in dogs can be a heartbreaking thing to watch as symptoms manifest in our once-healthy companion. We want so desperately to help, but we only feel helpless and lost for answers.

The good news is that Mother Nature came up with some very positive answers a long time ago. She gave us specific herbs containing phytonutrients that act on targeted organs, glands and systems to restore homeostasis, balance and wellness.

A Cushingoid dog’s road to recovery may have been engineered eons ago in the cells of special plants. Ayurvedic medicine was used thousands of years ago to treat symptoms that today we call Metabolic Syndrome in humans and, similarly, Cushings in dogs. Only in the last 60 or so years has modern medicine identified and verified through clinical trials specific herbs that take corrective actions on Cushing’s.

Our Primalix CortiQuel® for Cushing’s syndrome combines old wisdom with new science to deliver these powerful healing nutrients to the very glands whose imbalance has brought on Cushing’s. In researching our formula we uncovered findings that we think you’ll find quite remarkable, which we’ll cover below. But first …

What Causes Cushing’s?

Cushing’s syndrome (aka Cushing’s Disease) is brought on through a complex game of cat-and-mouse played out between the adrenal glands and the pituitary. To simplify things a bit, let’s say the pituitary gland, located at the base of the brain, is the Cat. The adrenalin glands, located near the kidneys, are the Mice.

In a healthy dog, Cat and Mice get along just fine. The Cat (pituitary gland) makes it her daily duty to carve out a nice wedge of cheddar cheese (which in this case is the secretion adrenocorticotrophic hormone or ACTH) and deliver it to her Mice friends (adrenalin glands) for their dining pleasure.

So grateful are the Mice for their daily cheese that they always return the favor by delivering two chunks of fine tuna fish (which in our story is the secretion of glucocorticoid hormones, or cortisol) for their Cat friend’s dining pleasure. Naturally, both Cat and Mice observe good manners by sending the other party a “Thank you” memo after eating their fill of each meal. And all is peaceful and happy because everybody communicates.

Then one day the Cat stops sending her thank you memo to the Mice for reasons that only rapscallion cats can explain, and everything begins to change. The Mice don’t know whether the Cat received their tuna (cortisol) so they quickly make more and send it to the Cat. Well, again the Cat eats the tuna fish and again fails to send back her thank you memo. So (you guessed it) the Mice make still more tuna (cortisol) and send it off to our now badly overstuffed Cat.

Nobody Got The Memo

This is how Cushings in dogs develops. The adrenalin glands (Mice) naturally produce glucocorticoid hormones or cortisol (tuna fish) at a rate in balance with the pituitary gland’s (Cat’s) production of ACTH (cheese). One feeds, and is fed by, the other.

But when the Cat pounds down too much tuna because the Mice keep making more (and hoping the Cat will return the favor with more cheese), a feedback loop of miscommunication occurs, and trouble ensues because nobody gets the memo. The result is hyperadrenocorticism – an excessive level of blood cortisol.

In about 85% of Cushings in dogs cases, the miscommunication begins with a tiny tumor that develops in the pituitary gland. Smaller than a pin point, this growth is usually benign but causes the pituitary to secrete ACTH non-stop. This signals the adrenals to churn out still more cortisol, yet the pituitary ignores the elevated blood cortisol levels and continues its release of ACTH. It’s all much more complex than my cat-and-mouse analogy, of course, but basically it’s a case of glands out of sync.

Symptoms of Cushings in Dogs

Gradually a Cushingoid dog will develop symptoms which can often be mistaken for normal signs of ageing or even signs of completely different health issues. The most common symptoms of Cushings in dogs include:

  • Excessive water consumption
  • Excessive urination
  • Loss of bladder control (accidents around the house)
  • Increased appetite, bot belly
  • Weight gain (mostly redistribution of fat)
  • Loss of muscle mass
  • Lethargy, weakness
  • Baldness or thinning hair
  • Calcified lumps in the skin
  • Weakened immune system
  • Pancreatitis and/or diabetes

Ironically, previous symptoms of inflammatory and auto-immune conditions may subside. Dogs with chronic allergies or rheumatoid arthritis may get “spontaneously” better when they develop Cushing's because of the flood of cortisone gushing through their veins, suppressing the immune system. This trade-off may prompt a loving dog owner to reconsider any treatment, or at least rethink any harsh or invasive procedure.

Why Balance is the Answer

Don’t get me wrong. Cortisol is a good thing. It’s one of life’s essentials. It is released in response to stress and impacts a number of biological systems and functions including:

  • skeletal muscles
  • cardiovascular system
  • blood sugar levels
  • kidney function
  • fat metabolism
  • nervous system
  • immune response

But when blood cortisol levels are elevated as they are in hyperadrenocorticism – Cushing’s – the sensible holistic approach is to nourish the very glands in question – the adrenals and pituitary. Remember, balance and wellness can be achieved with specific herbs that act on targeted organs, glands and systems. Let’s examine the ingredients in our herbal formula.

Primalix CortiQuel ®
Herbal Extract – Functional Food Drops™ - Ingredients

Rhodiola rosea root is a member of an elite group of herbs called adaptagens. These herbs perform the ultimate restoration project. They find physiological systems under stress and out of balance, and bring them into harmony and good health. Adaptagens are both stress-protective and immune system enhancing.

Russian scientist Dr. Nicolai Lazarev discovered adaptogens in 1947 and later coined the name "adaptogen." Hundreds of experimental and clinical studies on adaptogens have been conducted since then. Rhodiola was found to be cardio-protective, normalizing the heart rate immediately after intense exercise. It not only increases protein synthesis, but also improves the nervous system and mental functions such as memory, by increasing blood-supply to the muscles and brain.

In addition to the general healing benefits of Rhodiola root, the specific herbal action on your dog's Cushing's syndrome is a normalizing of the stress response together with a mediation of cortisol secretion levels.

Astragalus root's ability to optimize the immune system is well known. Less well known is this ancient herb's stress buffering effects. Stress related physical damage is minimized with the increased production of natural anti-stress compounds. Astragalus is also believed to interrupt the delivery of stress hormones like cortisol by reducing their ability to bind to receptors.

Dandelion root is used to cleanse the liver, kidneys and colon. It decongests the gallbladder by increasing bile production and flow. It also stimulates cell metabolism by assisting the body to dump metabolic waste into the blood to be cleansed by the liver. Dandelion root prepares a healthy work environment for the next three herbs in our formula.

Alfalfa is used for its known ability to promote pituitary gland function. It has been used by the Chinese for thousands of years to alleviate fluid retention and swelling. There are approximately 300 nutrients in addition to phyto-nutrients contained in alfalfa. These include protein, beta carotene, A, B1, B2, B5, B6, C, E, K, calcium, potassium, iron and zinc, all of which are essential for balanced nutrition. Alfalfa also lowers cholesterol and blood sugar levels, strengthens bone, alkalizes the system, reduces joint and muscle pain, reduces fatigue by providing more energy to the system, and effectively treats kidney stones and urinary tract disorders.

Shiitake mushroom is used as an anti-tumor agent. Several medicinal properties have been attributed to Shiitake in recent years. These properties include antitumor polysaccharides activity and glycoproteins, antiviral nucleic acids, platelet agglutination inhibitive substances, and anti-cholesterol active substances. While the mechanism of Shiitake’s antitumor action is not completely understood, these polysaccharides and polysaccharide-protein complexes are believed to enhance cell-mediated immune responses in vivo and in vitro and act as biological response modifiers.

Full Spectrum, Full Formula, Full Plant

Our extraction solvent (menstruum) consists of our own proprietary blend of organic vegetable glycerin, apple cider vinegar, and crystal clear water which we ionize and purify through filters measuring one one-hundredth of a micron. We do not extract with alcohol, which is harmful to dogs and cats, nor with heat which "denatures" the very herbal constituents that do the healing.

Our extraction solvent (menstruum) consists of our own proprietary blend of organic vegetable glycerin (very low glycemic load), apple cider vinegar, and crystal clear water which we ionize and purify through filters measuring one one-hundredth of a micron. We do not extract with alcohol, which is harmful to dogs and cats, nor with heat which "denatures" the very herbal constituents that do the healing.

Our herbs are organically cultivated (USDA Certified Organic or Wildharvested) to maintain purity. We then place them into our full spectrum extraction process one precious gallon at a time, at the peak of their potency cycle, agitating frequently for no less than a fortnight.

Ours is a time-honored tradition of tincturing that assures the constituent ratios in our extracts are identical to the synergistic nutrient ratios in the plants used.

We make and sell only our own products, so we know exactly what’s in them. We know of no other herbal extraction method that so painstakingly prepares Nature's bounty for our beloved animal companions.

Turn Ordinary Food Into Functional FoodSM

Our Primalix® CortiQuel for Cushing's Functional Food DropsTM let you add specific, beneficial, physiologically active food components (herbal nutrients) to wet or dry food.

Functional food is any food having health-promoting or disease-preventing properties beyond the basic function of supplying nutrients.

Nearly 2500 years ago Hippocrates said, “Let food be thy medicine and medicine be thy food.”

Animals do this instinctively. In the wild they “functionalize” their food by sniffing out and eating specific herbs to prevent disease and maintain natural wellness.

Now you can add function to any dry, canned, raw or homemade pet food. Give your domestic dog or cat a targeted dose of wild, natural wellness with every meal.

Dosing Instructions

Add to food:

Small Dogs (under 20 lbs) 1 dropper twice daily
Medium Dogs (20 to 60 lbs) 2 droppers twice daily
Large Dogs (61 to 100 lbs) 3 droppers twice daily
Giant Dogs (101 lbs and up) 4 droppers twice daily

NOTE: One "dropper" equals one squeeze of the black bulb (1.0mL), which fills the pipette about half full. Refrigerate after opening.

NOTE: CortiQuel for Cushings in Dogs is NOT recommended for pregnant or nursing animals or for dogs on blood-thinning or anti-rejection drugs.


Our Risk-Free Guarantee*

We're so sure you are going to be completely satisfied with Primalix® CortiQuel for Cushings in Dogs - Functional Food DropsTM that you have our ironclad, bottom-of-the-bottle Written Guarantee:

“Every bottle of Primalix® CortiQuel for Cushing's is guaranteed to meet your complete satisfaction or your money back! Simply return the unused portion to Natural Wonder Products within 30 days for a full refund of your purchase price (less S&H). No hassle, no questions asked. If you’re not happy, we’re not happy!”


How has CortiQuel helped others?


Primalix® CortiQuel for Cushings in Dogs - Herbal Extract - Functional Food Drops - $39.95 (Regular price $49.95) - 4 oz Glycerite (Amber Glass Tincture) Contains 120 droppers full. Organic, human grade ingredients. Up to 5 times more absorption than pills, tablets or granules.

NOTE: All Primalix products give you 2 to 4 times more medicine than our competitors' 1 or 2 ounce bottles that cost about the same and may contain harmful alcohol.


Limited Time Offer

Now, for a limited time, buy 3 bottles of Primalix® CortiQuel for Cushings in Dogs - Herbal Extract - Functional Food Drops - Regular price $149.85. Now only $119.85. SAVE $30.00!



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Information provided on this web site is intended for educational purposes only. Any statements made have not been evaluated by the FDA. No information provided on this web site is intended to prevent, diagnose, treat, or cure any symptom or disease. If you have questions about herbs or their chemical constituents, please see a licensed medical professional.